Explore the truth about CSU

Uncover 10 facts about chronic spontaneous urticaria (CSU) and dispel the myths about its management.

Making a difference in CSU starts with parsing out the facts and fiction surrounding its pathogenesis and burden on patients.

What percentage of patients with CSU remain symptomatic despite taking antihistamines?

TRUE OR FALSE: Urticaria treatment guidelines recommend steroids as part of the long-term treatment plan for CSU.

How many patients with CSU in the US are symptomatic despite treatment with antihistamines?

TRUE OR FALSE: External allergens trigger up to 15% of CSU cases.

If patients with CSU don’t respond to initial second-generation antihistamine therapy, what do urticaria treatment guidelines suggest?

Which immunoglobulin-mediated mechanisms are thought to drive immune dysregulation and mast cell activation in CSU: IgE or IgG?

TRUE OR FALSE: In CSU, Bruton's tyrosine kinase (BTK) is the central regulator of FcεRI-mediated functions.

TRUE OR FALSE: In CSU, corticosteroids typically provide a long-lasting effect once they’re discontinued.

TRUE OR FALSE: CSU is almost always swiftly identified and diagnosed.

TRUE OR FALSE: Histamine plays a role in the underlying pathogenesis of CSU.

Take a closer look at the internal drivers, treatments, and real consequences of CSU.

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FcεRI=high-affinity IgE receptor; IgE=immunoglobulin E; IgG=immunoglobulin G.

References:
1. Kaplan A, Lebwohl M, Giménez-Arnau AM, Hide M, Armstrong AW, Maurer M. Allergy. 2023;78(2):389–401. doi:10.1111/all.15603
2. Zuberbier T, Latiff AHA, Abuzakouk M, et al. Allergy. 2022;77(3):734–766. doi:10.1111/all.15090
3. Data on file. IQVIA LAAD APLD, extracted by NVS Global Business Solutions. Novartis Pharmaceuticals Corp; May 2023.
4. Maurer M, Eyerich K, Eyerich S, et al. Int Arch Allergy Immunol. 2020;181(5):321–333. doi:10.1159/000507218
5. Kolkhir P, Giménez-Arnau AM, Kulthanan K, Peter J, Metz M, Maurer M. Nat Rev Dis Primers. 2022;8(1):61. doi:10.1038/s41572-022-00389-z
6. Maurer M, Berger W, Giménez-Arnau A, et al. J Allergy Clin Immunol. Published online September 9, 2022. 2022;150(6):1498–1506.e2. doi:10.1016/j.jaci.2022.08.027
7. Ledford D, Broder MS, Antonova E, Omachi TA, Chang E, Luskin A. Allergy Asthma Proc. 2016;37(6):458–465. doi:10.2500/aap.2016.37.3999
8. Maurer M, Abuzakouk M, Bérard F, et al. Allergy. 2017;72(12):2005–2016. doi:10.1111/all.13209
9. Altman K, Chang C. Clin Rev Allergy Immunol. 2013;45(1):47–62. doi:10.1007/s12016-012-8326-y